Large doses of ferrous sulphate may have irritant and corrosive effects on the gastro-intestinal mucosa and necrosis and perforation may occur; stricture formation may subsequently follow. Symptoms, which may not appear for several hours, include epigastric pain, diarrhoea, vomiting, and haematemesis. Circulatory failure may follow if the diarrhoea and haemorrhage are severe. Hours of days later, after apparent recovery, metabolic acidosis, convulsions, and coma may occur. If the patient survives, symptoms of acute live necrosis may develop and may lead to death due to hepatic coma.
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